Selección de publicaciones

Aymerich MS, Aso E, Abellanas MA, Tolon RM, Ramos JA, Ferrer I, Romero J, Fernández-Ruiz J. Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system. Biochem Pharmacol. 2018 Nov;157:67-84.

Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco R, Aymerich MS. Fatty acid amide hydrolase for the symptomatic relief of Parkinson´s disease. Brain Behav Immun. 2016 57:94-105.

Cordon I, Nicolás MJ, Arrieta S, Alegre M, Artieda J, Valencia M. Theta-phase closed-loop stimulation induces motor paradoxical responses in the rat model of Parkinson disease. Brain Stimul. 2018 Jan - Feb;11(1):231-238

Cordon I, Nicolás MJ, Arrieta S, Lopetegui E, López-Azcárate J, Alegre M, Artieda J,Valencia M. Coupling in the cortico-basal ganglia circuit is aberrant in the ketamine model of schizophrenia. Eur Neuropsychopharmacol; 2015;25:1375–1387.

Cuadrado-Tejedor M, García-Barroso C, Sánchez-Arias JA, Rabal O, Pérez-González M, Mederos S, Ugarte A, Franco R, Segura V, Perea G, Oyarzabal J, García-Osta A. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology. 2017 Jan;42(2):524-539

Dautan, D., A.S. Souza, I. Huerta-Ocampo, M. Valencia, M. Assous, I.B. Witten, K. Deisseroth, et al. 2016. Segregated Cholinergic Transmission Modulates Dopamine Neurons Integrated in Distinct Functional Circuits. Nature Neuroscience 2016;19 (8):1025-1033. 

Delgado Alvarado M, Dacosta-Aguayo R, Navalpotro-Gómez I, B Gago, A Gorostidi, H Jiménez-Urbieta, J Ruiz-Martinez, A Bergareche, Rodríguez-Oroz MC. Ratios of proteins in cerebrospinal fluid in Parkinson’s disease cognitive decline: prospective study. Mov. Disord. Journal. 2018;33:1809-1813

Diez-Fairen M, Benitez BA, Ortega-Cubero S, Lorenzo-Betancor O, Cruchaga C, Lorenzo E, Samaranch L, Carcel M, Obeso JA, Rodriguez-Oroz MC, Aguilar M, Coria F, Pastor MA, Pastor P. Pooled-DNA target sequencing of Parkinson genes reveals novel phenotypic associations in Spanish population. Neurobiol Aging. 2018. doi: 10.1016/j.neurobiolaging.2018.05.008. [Epub ahead of print]

Diez-Fairen M, Benitez BA, Ortega-Cubero S, Lorenzo-Betancor O, Cruchaga C, Lorenzo E, Samaranch L, Carcel M, Obeso JA, Rodriguez-Oroz MC, Aguilar M, Coria F, Pastor MA, Pastor P. Pooled-DNA target sequencing of Parkinson genes reveals novel phenotypic associations in Spanish population. Neurobiol Aging. 2018 Oct;70:325.e1-325.e5.

Franco R, Martínez-Pinilla E, Lanciego JL, Navarro G. Basic pharmacological and structural evidence for class A G-protein-soupled receptor heteromerization. Front. Pharmacol. 2016, 7:76.

Íñigo-Marco I, Valencia M, Larrea L, Bugallo R, Martínez-Goikoetxea M, Zuriguel I, Arrasate M. E46K alpha-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation. Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8274-E8283.

Jiang L, Berraondo P, Jericó D, Guey LT, Sampedro A, Frassetto A, Benenato KE, Burke K, Santamaría E, Alegre M, Pejenaute Á, Kalariya M, Butcher W, Park JS, Zhu X, Sabnis S, Kumarasinghe ES, Salerno T, Kenney M, Lukacs CM, Ávila MA, Martini PGV, Fontanellas A. Systemic messenger RNA as an etiological treatment for acute intermittent porphyria. Nature Medicine 2018;24(12):1899-1909.

Jiménez-Urbieta H, Gago B, Quiroga-Varela A, Rodríguez Chinchilla T, L Merino-Galan, A Oregi, A Belloso-Iguerategui, M Delgado-Alvarado, I Navalpotro-Gómez, C Marin, Pierre-Olivier Fernagut, MC. Rodriguez-Oroz. Pramipexole-induced impulsivity in mild parkinsonian rats: a model of impulse control disorders in Parkinson’s disease Neurobiol Aging. 2019:126-135.

Martier R, Liefhebber JM, García-Osta A, Miniarikova J, Cuadrado-Tejedor M, Espelosin M, Ursua S, Petry H, van Deventer SJ, Evers MM, Konstantinova P. Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy. Mol Ther Nucleic Acids. 2019 Feb 11;16:26-37.

Martinez, M*; Valencia, M*; Vidorreta, M; Luis, EO; Castellanos, G; Villagra, F; Fernandez-Seara, MA; Pastor, MA. Trade-off between Frequency and Precision during Stepping Movements: Kinematic and BOLD Brain Activation Patterns. Hum Brain Mapp. 2016 May;37(5):1722-37.

Martínez-Pinilla E, Reyes-Resina I, Oñatibia-Astibia A, Zamarbide M, Ricobaraza A, Navarro G, Moreno E, Dopeso-Reyes IG, Sierra S, Rico AJ, Roda E, Lanciego JL*, Franco R*. CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum. Exp. Neurol. 2014, 261:44-52.

Pascual-Lucas M, Viana da Silva S, Di Scala M, Garcia-Barroso C, González-Aseguinolaza G, Mulle C, Alberini CM, Cuadrado-Tejedor M, Garcia-Osta A. Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. EMBO Mol Med. 2014;6(10):1246-62.

Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, De Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella A, Sáez E, Espelosin M, Ursua S, Tan H, Wu W, Xu M, Garcia-Osta A, Oyarzabal J. Discovery of in-vivo chemical probes for treating Alzheimer´s disease: Dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitors. ACS Chem Neurosci. 2018 Dec 10. doi: 10.1021/acschemneuro.8b00648.

Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J. Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Apr 25;150:506-524.

Rico AJ, Dopeso-Reyes IG, Martinez-Pinilla E, Sucunza D, Pignataro D, Roda E, Marin-Ramos D, Labandeira-Garcia JL, George SR, Franco R, Lanciego JL. Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. Brain Struct. Funct. 2017, 222:1767-1784.

Sierra S, Luquin N, Rico AJ, Gómez-Bautista V, Roda E, Dopeso-Reyes IG, Vázquez A, Martínez-Pinilla E, Labandeira-García JL, Franco R, Lanciego JL. Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques. Changes following experimental parkinsonism. Brain Struct Funct. 2015, 220:2721-2738.

Valencia M, Chavez M, Artieda J, Paul Bolam J, Mena-Segovia J. Abnormal functional connectivity between motor cortex and pedunculopontine nucleus following chronic dopamine depletion. J Neurophysiol. 2014;111(2):434-40.

Zamarbide M, Etayo-Labiano I, Ricobaraza A, Martínez-Pinilla E, Aymerich MS, Luis Lanciego J, Pérez-Mediavilla A, Franco R. GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. Hippocampus. 2014;24(7):733-9.

Zamarbide M, Gil-Bea FJ, Bannenberg P, Martínez-Pinilla E, Sandoval J, Franco R, Pérez-Mediavilla A. Maternal imprinting on cognition markers of wild type and transgenic Alzheimer's disease model mice. Sci Rep. 2018 Apr 24;8(1):6434. doi: 10.1038/s41598-018-24710-7.

 

*Equal contribution


Tratamos de identificar los factores que dan origen al proceso neurodegenerativo para diseñar nuevas estrategias experimentales que permitan detectar y tratar la enfermedad en fases tempranas.

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Contacto:
Cristina Canciani
Avda. Pío XII, 55
31008 Pamplona
España

(+34) 948 194 700 Ext. 2013
canciani@unav.es