Selección de publicaciones

Uerlings R, Moreno D, Murillo O, Gazquez C, Hernández-Alcoceba R, González-Aseguinolaza G, Weiskirchen R. Brain copper storage after genetic long-term correction in a mouse model of Wilson disease. Neurol Genet. 2018 May 18;4(3):e243.

Moreno D, Murillo O, Gazquez C, Hernandez-Alcoceba R, Uerlings R, Gonzalez-Aseguinolaza G, Weiskirchen R. Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry. J Hepatol. 2018 May;68(5):1088-1090.

Majowicz A, Salas D, Zabaleta N, Rodríguez-Garcia E, González-Aseguinolaza G, Petry H, Ferreira V. Successful Repeated Hepatic Gene Delivery in Mice and Non-human Primates Achieved by Sequential Administration of AAV5(ch) and AAV1. Mol Ther. 2017 Aug 2;25(8):1831-1842.

Zabaleta N, Salas D, Paramo M, Hommel M, Sier-Ferreira V, Hernandez-Alcoceba R, Prieto J, Bilbao JI, Gonzalez-Aseguinolaza G. Improvement of Adeno-Associated  Virus-Mediated Liver Transduction Efficacy by Regional Administration in Macaca fascicularis. Hum Gene Ther Clin Dev. 2017 Jun;28(2):68-73.

Pignataro D, Sucunza D, Vanrell L, Lopez-Franco E, Dopeso-Reyes IG, Vales A, Hommel M, Rico AJ, Lanciego JL, Gonzalez-Aseguinolaza G. Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System. Front Neuroanat. 2017 Feb 10;11:2.

Suárez-Amarán L, Usai C, Di Scala M, Godoy C, Ni Y, Hommel M, Palomo L, Segura V, Olagüe C, Vales A, Ruiz-Ripa A, Buti M, Salido E, Prieto J, Urban S, Rodríguez-Frias F, Aldabe R, González-Aseguinolaza G. A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-β induction. J Hepatol. 2017 Oct;67(4):669-679.

D'Avola D, López-Franco E, Sangro B, Pañeda A, Grossios N, Gil-Farina I, Benito A, Twisk J, Paz M, Ruiz J, Schmidt M, Petry H, Harper P, de Salamanca RE, Fontanellas A, Prieto J, González-Aseguinolaza G. Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria. JHepatol. 2016 Oct;65(4):776-783.

Gil-Farina I, Fronza R, Kaeppel C, Lopez-Franco E, Ferreira V, D'Avola D, Benito A, Prieto J, Petry H, Gonzalez-Aseguinolaza G, Schmidt M. Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and  Patients. Mol Ther. 2016 Jun;24(6):1100-1105.

Murillo O, Luqui DM, Gazquez C, Martinez-Espartosa D, Navarro-Blasco I, Monreal JI, Guembe L, Moreno-Cermeño A, Corrales FJ, Prieto J, Hernandez-Alcoceba R, Gonzalez-Aseguinolaza G. Long-term metabolic correction of Wilson's disease in a murine model by gene therapy. J Hepatol. 2016 Feb;64(2):419-426.

Di Scala M, Otano I, Gil-Fariña I, Vanrell L, Hommel M, Olagüe C, Vales A, Galarraga M, Guembe L, Ortiz de Solorzano C, Ghosh I, Maini MK, Prieto J, González-Aseguinolaza G. Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice. J Virol. 2016 Sep 12;90(19):8563-74.

Nistal-Villán E, Rodríguez-García E, Di Scala M, Ferrero-Laborda R, Olagüe C,  Vales Á, Carte-Abad B, Crespo I, García-Sastre A, Prieto J, Larrea E, González-Aseguinolaza G. A RIG-I 2CARD-MAVS200 Chimeric Protein Reconstitutes IFN-β Induction and Antiviral Response in Models Deficient in Type I IFN Response. J Innate Immun. 2015;7(5):466-81.

Berraondo P, Di Scala M, Korolowicz K, Thampi LM, Otano I, Suarez L, Fioravanti J, Aranda F, Ardaiz N, Yang J, Kallakury BV, Tucker RD, Vasquez M, Menne S, Prieto J, González-Aseguinolaza G. Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein  A-I. J Hepatol. 2015 Aug;63(2):329-36. 


"Para desarrollar nuevos tratamientos mediante terapia génica, utilizamos como vehículo uno de los vectores virales más seguros y eficaces que existen actualmente: el virus adenoasociado. Esperamos obtener en los próximos años un claro beneficio clínico en pacientes con enfermedades raras como la hiperoxaluria", Dra. Gloria González, directora del programa.

Síndrome de Dravet

Contacto

Contacto:
Cristina López
Avda. Pío XII, 55
31008 Pamplona
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(+34) 948 194 700 Ext. 6021
clopezg@unav.es