Selección de publicaciones

  • Quetglas J.I., Fioravanti J., Ardaiz N., Medina-Echeverz J., Baraibar I., Prieto, J. Smerdou C.*, Berraondo P.* (2012) A Semliki Forest virus vector engineered to express IFNa induces efficient elimination of established tumors. Gene Therapy. 19(3):271-8.

  • Quetglas J.I., Dubrot J., Bezunartea J., Sanmamed M.F., Hervas-Stubbs S., Smerdou C.*, Melero I.* (2012) Immunotherapeutic synergy between anti-CD137 mAb and intratumoral admistration of a cytopathic Semliki Forest virus encoding IL-12. Molecular Therapy. 20(9):1664-1675.

  • Quetglas J.I., John L.B., Kershaw M.H., Alvarez-Vallina L., Melero I., Darcy P.K, Smerdou C. (2012) Virotherapy, gene transfer and immunostimulatory monoclonal antibodies. OncoImmunology. 1:8, 1344-1354.

  • Quetglas J.I., Rodriguez-Madoz J.R., Bezunartea J., Ruiz-Guillen M., Casales E., Medina-Echeverz J., Prieto J., Berraondo P., Hervas-Stubbs S.*, Smerdou C*. (2013). Eradication of liver-implanted tumors by Semliki Forest virus expressing IL-12 requires efficient long-term immune responses. Journal of Immunology. 190:2994-3004.

  • Rodriguez-Madoz J.R., Zabala M., Alfaro M., Prieto J., Kramer M.G., Smerdou C. (2014). Short-term intra-tumoral IL-12 expressed from an alphaviral vector is sufficient to induce an efficient anti-tumoral response against spontaneous hepatocellular carcinomas. Human Gene Therapy. 25(2): 132-143.

  • Aranda A., Bezunartea J., Casales E., Rodriguez-Madoz J.R., Larrea E., Prieto J., Smerdou C. (2014). A quick and efficient method to generate mammalian stable cell lines based on a novel inducible alphavirus DNA/RNA layered system. Cellular and Molecular Life Sciences. 71(23):4637-51.

  • Melero I., Quetglas J.I., Reboredo M., Dubrot J., Rodriguez-Madoz J.R., Mancheño U., Casales E., Riezu-Boj J., Ruiz-Guillen M., Ochoa M.C., Sanmamed M.F., Thieblemont N., Smerdou C., Hervas-Stubbs S. (2015). Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL-12. Cancer Research. 75(3):497-507.

  • Quetglas J.I., Labiano S., Aznar A., Bolaños E., Azpilikueta A., Rodriguez I., Casales E., Rodríguez A.,  Smerdou C., and Melero I. (2015). Virotherapy with a Semliki Forest Virus-based Vector encoding IL-12 synergizes with PD-1/PD-L1 Blockade. Cancer Immunology Research. 3(5):449-54.

  • Kramer M.G., Masner M., Casales E., Moreno M., Smerdou C., Chabalgoity J.A.. (2015) Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice. BMC Cancer. Sep 7;15:620.

  • Hernandez-Alcoceba R., Poutou J., Ballesteros-Briones M.C., Smerdou C. (2016) Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of intereleukin-12. Immunotherapy. 8(2):179-198

  • Ruiz-Guillen M., Gabev E., Quetglas J.I., Casales E., Ballesteros-Briones M.C., Poutou J., Aranda A., Martisova E., Bezunartea J., Ondiviela M., Prieto J., Hernandez-Alcoceba R., Abrescia N.G.A., Smerdou C. (2016). Capsid-Deficient Alphaviruses Generate Propagative Infectious Microvesicles at the Plasma Membrane. Cellular and Molecular Life Sciences. 73(20):3897-916.

  • Ruiz-Guillen M., Abrescia N.G.A., Smerdou C. (2017). Neurotropic alphaviruses can propagate without capsid. Oncotarget. 8(6):8999-9000.

  • Gato-Cañas M, Zuazo M, Arasanz H, Ibañez-Vea M, Lorenzo L, Fernandez-Hinojal G, Vera R, Smerdou C, Martisova E, Arozarena I, Wellbrock C, Llopiz D, Ruiz M, Sarobe P, Breckpot K, Kochan G, Escors D. (2017). PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity. Cell Reports. 2017 Aug 22;20(8):1818-1829.

  • Sánchez-Paulete A.R., Teijeira A., Quetglas J.I., Rodríguez-Ruiz M.E., Sánchez-Arráez A., Labiano S., Etxeberria I., Azpilikueta A., Bolaños E., Ballesteros-Briones M.C., Casares N., Quezada S.A., Berraondo P., Sancho D., Smerdou C.*, Melero I.* (2018) Intratumoral immunotherapy with XCL1 and sFlt3L encoded in recombinant Semliki Forest Virus-derived vectors to foster dendritic cell-mediated T-cell cross-priming. Cancer Research. In press



"Estamos evaluando el uso de anticuerpos monoclonales (MAbs) con propiedades inmunomoduladoras para el tratamiento del cáncer", Dr. Cristian Smerdou, investigador principal.

Contacto

Contacto:
Cristina López
Avda. Pío XII, 55
31008 Pamplona
España

(+34) 948 194 700 Ext. 6021
clopezg@unav.es