Selección de publicaciones

  • Alves S, Neiri L, Chaves SR, Vieira S, Trindade D, Manon S, Dominguez V, Pintado B, Jonckheere V, Van Damme P, Silva RD, Aldabe R*, Côrte-Real M*. N-terminal acetylation modulates Bax targeting to mitochondria. Int J Biochem Cell Biol. 95:35-42. 2018

  • Suárez-Amarán L, Usai C, Di Scala M, Godoy C, Ni Y, Hommel M, Palomo L, Segura V, Olagüe C, Vales A, Ruiz-Ripa A, Buti M, Salido E, Prieto J, Urban S, Rodríguez-Frias F, Aldabe R, González-Aseguinolaza G. A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-β induction. J Hepatol. 67(4):669-679. 2017

  • Neri L, Lasa M, Elosegui-Artola A, D'Avola D, Carte B, Gazquez C, Alve S, Roca-Cusachs P, Iñarrairaegui M, Herrero J, Prieto J, Sangro B, Aldabe R. NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma. Oncotarget. 8(25):40967-40981. 2017

  • Moreno D, Neri L, Vicente E, Vales A, Aldabe R. Use of Thymidine Kinase Recombinant Adenovirus and Ganciclovir Mediated Mouse Liver Preconditioning for Hepatocyte Xenotransplantation. Methods Mol Biol. 1506:179-192. 2017

  •  Aldabe R, Suárez-Amarán L, Usai C, González-Aseguinolaza G. Animal models of chronic hepatitis delta virus infection host-virus immunologic interactions. Pathogens. 4(1):46-65. 2015

  • Duret C, Moreno D, Balasiddaiah A, Roux S, Briolotti P, Raulet E, Herrero A, Ramet H, Biron-Andreani C, Gerbal-Chaloin S, Ramos J, Navarro F, Hardwigsen J, Maurel P, Aldabe R, Daujat-Chavanieu M. Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy. Cell Transplant. 24(12):2541-55. 2015

  • Elosegui-Artola A, Jorge-Peñas A, Moreno-Arotzena O, Oregi A, Lasa M, García-Aznar JM, De Juan-Pardo EM, Aldabe R. Image analysis for the quantitative  comparison of stress fibers and focal adhesions. PLoS One. 9(9):e107393. 2014

  • Moreno D, Balasiddaiah A, Lamas O, Duret C, Neri L, Guembe L, Galarraga M, Larrea E, Daujat-Chavanieu M, Muntane J, Maurel P, Riezu JI, Prieto J, Aldabe R.  Usage of adenovirus expressing thymidine kinase mediated hepatocellular damage for enabling mouse liver repopulation with allogenic or xenogenic hepatocytes. PLoS One. 8(9):e74948. 2013

  • Balasiddaiah A, Moreno D, Guembe L, Prieto J, Aldabe R. Hepatic differentiation of mouse iPS cells and analysis of liver engraftment potential of multistage iPS progeny. J Physiol Biochem. 69(4):835-45. 2013

  • Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 109(31):12449-54. 2012

  • Benedicto I, Molina-Jiménez F, Bartosch B, Cosset FL, Lavillette D, Prieto J, Moreno-Otero R, Valenzuela-Fernández A, Aldabe R, López-Cabrera M, Majano PL. The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. J Virol. 83(16):8012-20. 2009

  • Liu J, HuangFu WC, Kumar KG, Qian J, Casey JP, Hamanaka RB, Grigoriadou C, Aldabe R, Diehl JA, Fuchs SY. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe. 5(1):72-83. 2009

  • Benedicto I, Molina-Jiménez F, Barreiro O, Maldonado-Rodríguez A, Prieto J, Moreno-Otero R, Aldabe R, López-Cabrera M, Majano PL. Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum. Hepatology. 48(4):1044-53. 2008

  • Ametzazurra A, Larrea E, Civeira MP, Prieto J, Aldabe R. Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis. Oncogene. 27(58):7296-306. 2008

  • Luquin E, Larrea E, Civeira MP, Prieto J, Aldabe R. HCV structural proteins interfere with interferon-alpha Jak/STAT signalling pathway. Antiviral Res. 76(2):194-7. 2007



"Hemos identificado moléculas pequeñas capaces de inhibir la enzima NatB y que podrían ser la base de una nueva terapia antitumoral y antimetastásica", Dr. Rafael Aldabe, investigador principal.

Contacto

Contacto:
Cristina López
Avda. Pío XII, 55
31008 Pamplona
España

(+34) 948 194 700 Ext. 6021
clopezg@unav.es