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Proyecto Hepacare

Selección de publicaciones

Programa de Hepatología

> Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, Fondevilla C, Stärkel P, Dubuquoy L, Louvet A, Odena G, Gomez JL, Aragon T, Altamirano J, Caballeria J, Jurczak MJ, Taylor DL, Berasain C, Wahlestedt C, Monga SP, Morgan MY, Sancho-Bru P, Mathurin P, Furuya S, Lackner C, Rusyn I, Shah VH, Thursz MR, Mann J, Avila MA, Bataller R.
Nat Commun. 2019 Jul 16;10(1):3126. doi: 10.1038/s41467-019-11004-3.
PMID:31311938

> Chromatin dynamics during liver regeneration

Arechederra M, Berasain CAvila MA, Fernández-Barrena MG.
Semin Cell Dev Biol. 2019 Apr 9. pii: S1084-9521(18)30193-9. doi: 10.1016/j.semcdb.2019.03.004. [Epub ahead of print] Review.
PMID:30940574

> Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins

Jiménez M, Urtasun R, Elizalde M, Azkona M, Latasa MU, Uriarte I, Arechederra M, Alignani D, Bárcena-Varela M, Álvarez-Sola G, Colyn L, Santamaría E, Sangro B, Rodriguez-Ortigosa C, Fernández-Barrena MG, Ávila MABerasain C.
Nucleic Acids Res. 2019 Apr 23;47(7):3450-3466. doi: 10.1093/nar/gkz014.
PMID:30657957

> The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis

Santamaría E, Rodríguez-Ortigosa CM, Uriarte I, Latasa MU, Urtasun R, Alvarez-Sola G, Bárcena-Varela M, Colyn L, Arcelus S, Jiménez M, Deutschmann K, Peleteiro-Vigil A, Gómez-Cambronero J, Milkiewicz M, Milkiewicz P, Sangro B, Keitel V, Monte MJ, Marin JJG, Fernández-Barrena MG, Ávila MABerasain C.
Hepatology. 2019 Apr;69(4):1632-1647. doi: 10.1002/hep.30348. Epub 2019 Mar 4.
PMID:30411380

> Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma

Bárcena-Varela M, Caruso S, Llerena S, Álvarez-Sola G, Uriarte I, Latasa MU, Urtasun R, Rebouissou S, Alvarez L, Jimenez M, Santamaría E, Rodriguez-Ortigosa C, Mazza G, Rombouts K, San José-Eneriz E, Rabal O, Agirre X, Iraburu M, Santos-Laso A, Banales JM, Zucman-Rossi J, Prósper F, Oyarzabal J, Berasain C, Ávila MA, Fernández-Barrena MG.
Hepatology. 2019 Feb;69(2):587-603. doi: 10.1002/hep.30168. Epub 2019 Jan 4.
PMID:30014490

> Splicing alterations contributing to cancer hallmarks in the liver: central role of dedifferentiation and genome instability

Jimenez M, Arechederra M, Ávila MABerasain C.
Transl Gastroenterol Hepatol. 2018 Oct 31;3:84. doi: 10.21037/tgh.2018.10.11. eCollection 2018. Review.
PMID:30505971

> Fibroblast growth factors 19 and 21 in acute liver damage

Shan Z, Alvarez-Sola G, Uriarte I, Arechederra M, Fernández-Barrena MG, Berasain C, Ju C, Avila MA.
Ann Transl Med. 2018 Jun;6(12):257. doi: 10.21037/atm.2018.05.26. Review.
PMID:30069459

Selección de publicaciones

Programa de Inmunología e Inmunoterapia

> Getting insights into hepatocellular carcinoma tumour heterogeneity by multiomics dissection”

Sarobe P, Corrales F.
Gut. 2019 Nov;68(11):1913-1914.

> When Cancer Vaccines Go Viral

Repáraz D, Llopiz D, Sarobe P.
Clin Cancer Res. 2019 Aug 15;25(16):4871-4873.

> Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model

Llopiz D, Ruiz M, Villanueva L, Iglesias T, Silva L, Egea J, Lasarte JJ, Pivette P, Trochon-Joseph V, Vasseur B, Dixon G, Sangro B, Sarobe P.
Cancer Immunol Immunother. 2019 Mar;68(3):379-393.

> Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related
IL-10

Llopiz D, Ruiz M, Silva L, Sarobe P.
Front Immunol. 2018 Sep 3;9:1923.

> Therapeutic Effect of Irreversible Electroporation in Combination with Poly-ICLC Adjuvant in Preclinical Models of Hepatocellular Carcinoma

Vivas I, Iribarren K, Lozano T, Cano D, Lasarte-Cia A, Chocarro S, Gorraiz M, Sarobe P, Hervás-Stubbs S, Bilbao JI, Casares N, Lasarte JJ.
J Vasc Interv Radiol. 2019 Jul;30(7):1098-1105. DOI:10.1016/j.jvir.2019.02.023.

> Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor.

Lozano T, Gorraiz M, Lasarte-Cía A, Ruiz M, Rabal O, Oyarzabal J, Hervás-Stubbs S, Llopiz D, Sarobe P, Prieto J, Casares N, Lasarte JJ.
Oncotarget. 2017 May 13;8(42):71709-71724. doi: 10.18632/oncotarget.17845.

> Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms.

Celay J, Lozano T, Concepcion AR, Beltrán E, Rudilla F, García-Barchino MJ, Robles EF, Rabal O, de Miguel I, Panizo C, Casares N, Oyarzabal J, Prieto J, Medina JF, Lasarte JJ, Martínez-Climent JÁ.
Haematologica. 2018 Jun;103(6):1065-1072. doi: 10.3324/haematol.2017.175687.

> Genetic modification of CD8 + T cells to express EGFR: potential application for adoptive T cell therapies. Running title: EGFR-CD8 + T-cells for ACT.

Teresa Lozano,Silvia Chocarro, Celia Martin, Aritz Lasarte-Cía, Cyntia Del Valle, Marta Gorraiz, Patricia Sarrión, Marina Ruiz, Amaia Lujambio, Sandra Hervas Stubbs, Pablo Sarobe, Noelia Casares and Juan José Lasarte.
Frontiers in Immunology, 2020, In press.

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