Our work is aimed at characterizing the dynamics of cerebral systems in normal conditions and when they are affected by neurological diseases (epilepsy, Parkinson's, Alzheimer's). The approach is based on the following: 1) using systems neurophysiology tools to identify the neurofunctional domains affected in mouse models and in patients, and 2) evaluating the effects of pharmacological and physical treatments (electrical and/or magnetic stimulation) and genetic manipulation of signaling molecules/pathways specific to these dynamics. The ultimate goal is to test new therapeutic approaches aimed at restoring normal cerebral dynamics.
The main projects of the laboratory to the following:
Evaluation of neurophysiological activity in patients and animal models of Parkinson's disease.
Evaluation of the therapeutic value of electrical and pharmacological neuromodulation of oscillatory activity in Parkinson's disease.
Neurophysiological and behavioral characterization of animal models of Alzheimer's disease.
To this end, we use clinical and experimental techniques that cover a broad spectrum of forms of recording neurophysiological data: EEG, EMG, ECoG and deep-brain activity in humans, and records in chronic and acute preparations in animal experimentation models. Our group is able to develop its own experimental tools, including the development of techniques for data analysis, building recording electrodes, chronic implantation systems and cognitive tests. These abilities give rise to collaboration with other laboratories of the neuroscience program and other national and international research centers.
"We study the dynamics of electrical activity in different brain systems under normal conditions and in different neurological diseases (epilepsy, Parkinson's, Alzheimer's) in order to develop new biomarkers for early diagnosis and to develop new therapeutic tools and strategies, based on the neuromodulation of these biomarkers", Dr. Julio Artieda.