• Ugarte A, Gil-Bea F, García-Barroso C, Cedazo-Minguez A, Ramírez MJ, Franco R, García-Osta A, Oyarzabal J, Cuadrado-Tejedor M. Decreased levels of cGMP in CSF are associated with cognitive decline and amyloid pathology in Alzheimer's disease. Neuropathol Appl Neurobiol. 2015 Jun;41(4):471-82.

  • Pascual-Lucas M, Viana da Silva S, Di Scala M, Garcia-Barroso C, González-Aseguinolaza G, Mulle C, Alberini CM, Cuadrado-Tejedor M, Garcia-Osta A. Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. EMBO Mol Med. 2014, 6 (10):1246-62.

  • Zamarbide M, Etayo-Labiano I, Ricobaraza A, Martínez-Pinilla E, Aymerich MS, Luis Lanciego J, Pérez-Mediavilla A, Franco R. GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. Hippocampus. 2014 Jul;24(7):733-9. doi: 10.1002/hipo.22263. Epub 2014 Feb 27.

  • Zamarbide M, Martinez-Pinilla E, Ricobaraza A, Aragón T, Franco R, Pérez-Mediavilla A. Phenyl acyl acids attenuate the unfolded protein response in tunicamycin-treated neuroblastoma cells. PLoS One. 2013 Aug 15;8(8

  • García-Barroso C, Ricobaraza A, Pascual-Lucas M, Unceta N, Rico AJ, Goicolea MA, Sallés J, Lanciego JL, Oyarzabal J, Franco R, Cuadrado-Tejedor M, García-Osta A. Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD. Neuropharmacology. 2013; 64:114-23

  • Ricobaraza A, Cuadrado-Tejedor M, Marco S, Perez-Otaño I, GARCIA-OSTA  A. Phenylbutyrate rescues spine loss associated with memory deficits in a mouse model of  Alzheimer's disease. Hippocampus. 2012; 22(5):1040-50.

  • Ricobaraza A, Cuadrado-Tejedor M, Pérez-Mediavilla A, Frechilla D, Del Río J, García-Osta A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology. 2009;34(7):1721-32. 

"We work to identify and perform preclinical validation of new therapeutic targets that may be used to develop molecules that can halt the development of Alzheimer's disease", Dra. Ana García-Osta.

More information:


Cristina Canciani
Avda. Pío XII, 55
31008 Pamplona

(+34) 948 194 700 Ext. 2013