Neurological diseases, and particularly neurodegenerative diseases, are highly prevalent and pose a public health problem. The Neuroscience Program focuses on the study of the most prevalent and disabling neurodegenerative diseases that occur with dementia and movement disorders, mainly Alzheimer's disease and Parkinson's disease. Currently, there are no therapies capable of curing or delaying the evolution of these diseases. Our research focuses on three complementary aspects:
1. To identify the mechanisms underlying neurodegenerative process by studying the molecular and cellular bases of synaptic dysfunction and neuronal death
2. To develop new disease-modifying therapies targeting the identified dysfunctions
3. To identify new biomarkers for the early diagnostic, evolution and prognosis of of these diseases.
These are translational research projects carried out using from cellular and animal models to studies in patients. A global and multidisciplinary approach is carried out through behavioral tests, molecular and cellular biology, biochemistry, electrophysiology, genetics and epigenetics, bioinformatics, neuroimaging, gene therapy, pharmacology, etc.
Another of our research lines focuses on the study of drug-resistant epilepsies through the analysis of genetic alterations and risk factors associated with the poor response to treatments. The results will used to develop new animal models and new treatments.
The neuroscience program is made up of a multidisciplinary research team, mainly comprised of researchers experts in the different areas of study (biologists, biochemists, medical doctors, pharmacists, engineers, psychologists, bioinformatics, etc.).
The Program receives funding from local, national, and international research agencies and private fund-raising initiatives. Among international projects, the program awarded grants from European Commission (7th Framework Program), the Michael J Fox Foundation, the Hereditary Disease Foundation, and the European Research Council. Laboratories of the program are members of the Center for Biomedical Research on Neurodegenerative Diseases (CiberNed). They maintain extensive collaborations with national and international groups that promote the exchange of resources and technology, and enrich the training of predoctoral and postdoctoral students and researchers.
Fecha de actualización: Junio 2019
We try to identify the factors that give rise to the neurodegenerative process to design new experimental strategies that allow detecting and treating the disease in early stages.