• Navarro-Oviedo M, Roncal C, Salicio A, Belzunce M, Rabal O, Toledo E, Zandio B, Rodríguez JA, Páramo JA, Muñoz R, Orbe J. MMP10 promotes efficient thrombolysis after ischemic stroke in mice with induced diabetes.Transl Stroke Res. 2018 Jul 27. doi: 10.1007/s12975-018-0652-9. IF (2017): 8,2; Lugar:41/362 Cardiology & Cardiovascular Medicine; 1er cuartil.

  • Rodriguez JA, Orbe J, Saenz-Pipaon G, Abizanda G, Gebara N, Radulescu F, Azcarate PM, Alonso-Perez L, Merino D, Prosper F, Paramo JA, Roncal C. Selective  increase of cardiomyocyte derived extracellular vesicles after experimental myocardial infarction and functional effects on the endothelium. Thromb Res. 2018 Aug 1;170:1-9. doi: 10.1016/j.thromres.2018.07.030. IF (2017): 2,8; Lugar:31/71 Hematology, 2º cuartil.

  • de Miguel I, Orbe J, Sánchez-Arias JA, Rodríguez JA, Salicio A, Rabal O, Belzunce M, Sáez E, Xu M, Wu W, Tan H, Ma H, Páramo JA, Oyarzabal J. Phenotypic screening to discover novel chemical series as efficient antihemorrhagic agents. ACS Med. Chem. Lett, 2018;9(5):428-433. IF(2017): 3,8; Lugar:12/59 Chemistry, Medicinal; 1er cuartil.

  • Roncal C, Martinez de Lizarrondo S, Salicio A, Chevilley A, Rodriguez JA, Rosell A, Couraud PO, Weksler B, Montaner J, Vivien D, Páramo JA, Orbe J. New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tPA. Cardiovasc Res. 2017;113(10):1219-1229.IF(2017): 6,3; Lugar:16/128 Cardiac & Cardiovascular systems; 1er cuartil.

  • Rodríguez JA, Sobrino T, López-Arias E, Ugarte A,  Sánchez-Arias JA, Vieites-Prado A, de Miguel I, Oyarzabal J, Páramo JA, Campos F, Orbe J, Castillo J. CM352 reduces brain damage and improves functional recovery in a rat model of intracerebral hemorrhage. J Am Heart Assoc. 2017 1;6(6). pii: e006042. doi: 10.1161/JAHA.117.006042. IF (2017): 4,6; Lugar: 36/128 Cardiac & Cardiovascular Systems, 2º cuartil.

  • Martinez-Aguilar E,  Orbe J, Fernández-Montero A, Fernández-Alonso S, Rodríguez JA, Fernández-Alonso L, Páramo JÁ, Roncal C. Reduced HDL-C: a valuable, independent prognostic marker in peripheral arterial disease. J Vasc Surg. 2017;66:1527-1533.IF(2017):3,3; Lugar:34/200 Surgery; 1er cuartil.

  • Allende M, Molina E, Lecumberri R, Sanchez-Arias JA, Ugarte A, Guruceaga E, Oyarzabal J, Hermida J. Inducing heat shock protein 70 expression provides a robust antithrombotic effect with minimal bleeding risk. Thromb Haemost. 2017;117:1722-1729. IF(2017); 4,9; Lugar:6/65 peripheral vascular disease; 1er decil.

  • Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, El Amki M, Fatar M, Garcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D. Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis. Stroke. 2016;47:1312-8. IF(2016); 6,0; Lugar:4/65 peripheral vascular disease; 1er decil.

  • Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJS. Activated protein C β-glycoform mediates superior cellular resistance to inflammation and ischemic injury. Blood 2015;126:915-9. IF (2013): 9,8; Lugar: 2/68 Hematology; 1er decil.

  • Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA. Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-m ethylbenzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med Chem. 2015;58(7):2941-57. IF (2013): 5,5; Lugar: 3/58 Chemistry, Medicinal; 1er decil.

  • Gomez-Rodriguez V, Orbe J, Martinez-Aguilar E, Rodriguez JA, Fernandez-Alonso L, Serneels J, Bobadilla M, Perez-Ruiz A, Collantes M, Mazzone M, Paramo JA, Roncal C. Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia. FASEB J. 2015;29(3):960-72. IF (2013): 5,5; Lugar: 7/85 Biology; 1er decil.

  • Martinez-Aguilar E, Gomez-Rodriguez V, Orbe J, Rodriguez JA, Fernández-Alonso L, Roncal C, Páramo JA. Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease.J Vasc Surg. 2015 Feb;61(2):428-35. IF (2013): 3,0; Lugar: 30/204 Surgery; 1er cuartil.

  • Tamayo I, Velasco SE, Puy C, Esmon CT, Dichiara MG, Montes R, Hermida J. Group V secretory phospholipase A2 impairs endothelial protein C receptor-dependent protein C activation and accelerates thrombosis in vivo. J Thromb Haemost. 2014;12(11):1921-7. IF (2013): 5,6; Lugar: 7/68 Hematology; 1er cuartil.

  • Toni M, Hermida J, Goñi MJ, Fernández P, Parks WC, Toledo E, Montes R, Díez N. Matrix metalloproteinase-10 plays an active role in microvascular complications in type 1 diabetic patients. Diabetologia. 2013;56(12):2743-52. IF (2013): 6,9; Lugar: 11/124 Endocrinology & Metabolism; 1er decil.

  • Rodríguez JA, Sobrino T, Orbe J, Purroy A, Martínez-Vila E, Castillo J, Páramo JA. proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke. J Thromb Haemost. 2013;11(8):1464-73. IF (2013): 5,6; Lugar: 7/68 Hematology; 1er cuartil.

  • Hernández C, Orbe J, Roncal C, Alvarez-Hernandez M, Martinez de Lizarrondo S, Alves MT, García Mata J, Páramo JA. Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients. Thromb Haemost. 2013;110(3):598-608. IF (2013): 5,8; Lugar: 6/68 Hematology; 1er decil.

"We've carried out clinical trials in patients with clinical and subclinical atherosclerosis, which suggest that MMP-10 may be a biomarker for vascular risk", Dra. Josune Orbe, Principal Investigator .


Nerea Cano
Avda. Pío XII, 55
31008 Pamplona

(+34) 948 194 700 Ext. 3044