Abstract: Peptides are molecules that are very useful as in vitro chemical probes in therapeutic strategies that involve breaking protein-protein interactions. They are an emerging class of therapeutic targets.
Synthetic peptides are a very useful tool when searching for new drugs; in fact, this type of chemical probe is very useful in therapeutic strategies that involve breaking protein-protein interactions (emerging class of therapeutic targets) and protein-DNA reactions. In addition, they continue to be an important strategy in the development of new therapeutic agents and new diagnostic methods.
Our research group has worked for more than 20 years on the synthesis of peptides and their application in diagnostic and therapeutic fields. We have developed diagnostic kits for hepatitis C infection (detection and serotyping), inhibitory peptides from immunosuppressant and/or fibrinogenic molecules, interleukin 10, and transcription factors such as Foxp3 and metaloproteinases such as MMP-10. They have also been used in the development of vaccination strategies and in immune response monitoring trials in patients with cancer and chronic infections. Other applications of peptides are as a tool for obtaining immunologic reagents (antibodies) for the detection of proteins in serum and tissue samples.