Long noncoding RNA and Gene Regulation in Cancer
One of the most remarkable scientific discoveries of the last decade came about thanks to the sequencing of the entire human transcriptome. It is now obvious that the majority of the cellular transcripts are produced from “non conventional” genes that do not code for proteins, and a very significant fraction of them are long noncoding RNAs (lncRNAs). Our group and others have shown that lncRNAs, despite not coding for proteins, regulate genome functions and gene expression, and that alterations in lncRNAs are inherent to human disease. For instance, we have found that lncRNAs have critical functions associated with tumor suppressors or oncogenes, such as p53 or MYC, playing key roles in cell transformation. However, our understanding of lncRNA functions and the underlying molecular mechanism are still extremely poor.
Our group focuses its efforts on investigating how lncRNAs influence the regulation, propagation and expression of the genome, and how these functions are altered in cancer, which is key for the development of improved diagnostics and therapies. To that end, we combine the implementation of genomics and epigenomics techniques, molecular biology as well as the analysis of patient samples.
Do you want to join our team?
We are searching for talented and highly motivated lab technicians, students and postdocs to work with us. If you are interested please contact Maite Huarte email@example.com
Fecha de actualización: Noviembre 2018