Publicaciones

  • Fresquet V, Rieger M, Carolis C, García-Barchino MJ, Martinez-Climent JA. Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma. Blood. 2014 Jun 26;123(26):4111-9.
    ABSTRACT CORTESÍA DE PUBMED

  • Sagardoy A, Martinez-Ferrandis JI, Roa S, Bunting K, Aznar A, Elemento O, Fontan L, Shaknovich R, Fres- quet V, Robles EF, Sagaert X, Melnick A*, Martinez-Climent JA*. Downregulation of FOXP1 is required during germinal center B-cell function. Blood, 2013 May 23;121(21):4311-20. (*) Co-autores senior
    ABSTRACT CORTESÍA DE PUBMED

  • Rapino F, Robles EF, Richter-Larrea JA, Kallin EM, Martinez-Climent JA*, Graf T*. C/EBPα induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity. Cell Rep. 2013 Apr 25;3(4):1153-63. (*) Co-autores senior
    ABSTRACT CORTESÍA DE PUBMED

  • Vicente-Dueñas C, Fontan L, Gonzalez-Herrero I, Romero-Camarero I, Segura V, Aznar MA, Sagardoy A, Bertolo C, Agirre X, Lossos IS, Hernandez-Rivas JM, Gonzalez M, Salar A, Bellosillo B, Conde E, Siebert R, Prosper F, Sagaert X, Cobaleda C, Sanchez-Garcia I*, Martinez-Climent JA*. Expression of MALT1 oncogene in mouse hematopoietic stem/progenitor cells recapitulates the pathogenesis of human MALT lymphoma. Proc. Natl. Acad. Sci. U. S. A. 2012 Jun 26;109(26):10534-9. (*) Co-autores senior
    ABSTRACT CORTESÍA DE PUBMED

  • Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24.
    ABSTRACT CORTESÍA DE PUBMED

  • Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S. The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. J Exp Med. 2012 Apr 9;209(4):671-8.
    ABSTRACT CORTESÍA DE PUBMED

  • Beltran E, Fresquet V, Martinez-Useros J, Richter-Larrea JA, Sagardoy A, Sesma I, Almada LL, Montes-Mo- reno S, Siebert R, Gesk S, Calasanz MJ, Malumbres R, Rieger M, Prosper F, Lossos IS, Piris MA, Fernan- dez-Zapico ME, Martinez-Climent JA. A cyclin-D1 interaction with BAX underlies its oncogenic role and poten- tial as a therapeutic target in mantle cell lymphoma. Proc Natl Acad Sci U. S. A. 2011 Jul 26;108(30):12461-6. 
    ABSTRACT CORTESÍA DE PUBMED
     



"Desarrollamos moléculas y estrategias terapéuticas especialmente en leucemias y linfomas B que no disponen de tratamientos satisfactorios", Dr. José A. Martínez Climent, investigador principal.

 

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Contacto:
Marisol Ripa
Avda. Pío XII, 55
31008 Pamplona
España

(+34) 948 194 700 Ext. 1010
msripa@unav.es