Publicaciones

  • Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation. Lozano T, Villanueva L, Durántez M, Gorraiz M, Ruiz M, Belsúe V, Riezu-Boj JI, Hervás-Stubbs S, Oyarzábal J, Bandukwala H, Lourenço AR, Coffer PJ, Sarobe P, Prieto J, Casares N, Lasarte JJ. J Immunol. 2015 Oct 1;195(7):3180-9. 
    ABSTRACT CORTESÍA DE PUBMED

  • Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression. Unzu C, Hervás-Stubbs S, Sampedro A, Mancheño U, Morales-Kastresana A, Serrano-Mendioroz I, de Salamanca RE, Benito A, Fontanellas A. Gene Ther. 2015 Jul 23. 
    ABSTRACT CORTESÍA DE PUBMED

  • Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12. Melero I, Quetglas JI, Reboredo M, Dubrot J, Rodriguez-Madoz JR, Mancheño U, Casales E, Riezu-Boj JI, Ruiz-Guillen M, Ochoa MC, Sanmamed MF, Thieblemont N, Smerdou C, Hervas-Stubbs S. Cancer Res. 2015 Feb 1;75(3):497-507. 
    ABSTRACT CORTESÍA DE PUBMED

  • Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming. Hervas-Stubbs S, Riezu-Boj JI, Mancheño U, Rueda P, Lopez L, Alignani D, Rodríguez-García E, Thieblemont N, Leclerc C. J Immunol. 2014 Aug 1;193(3):1151-61.
    ABSTRACT CORTESÍA DE PUBMED 

  • Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver. Alzuguren P, Hervas-Stubbs S, Gonzalez-Aseguinolaza G, Poutou J, Fortes P, Mancheno U, Bunuales M, Olagüe C, Razquin N, Van Rooijen N, Enguita M, Hernandez-Alcoceba R. Liver Int. 2015 Apr;35(4):1274-89. 
    ABSTRACT CORTESÍA DE PUBMED

  • The immunological profile of tumor-bearing animals determines the outcome of cancer immunotherapy. Quetglas JI, Hervas-Stubbs S, Smerdou C. Oncoimmunology. 2013 Jun 1;2(6):e24499. 
    ABSTRACT CORTESÍA DE PUBMED

  • Eradication of liver-implanted tumors by Semliki Forest virus expressing IL-12 requires efficient long-term immune responses. Quetglas JI, Rodriguez-Madoz JR, Bezunartea J, Ruiz-Guillen M, Casales E, Medina-Echeverz J, Prieto J, Berraondo P, Hervas-Stubbs S, Smerdou C. J Immunol. 2013 Mar 15;190(6):2994-3004. 
    ABSTRACT CORTESÍA DE PUBMED

  • Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb. Morales-Kastresana A, Catalán E, Hervás-Stubbs S, Palazón A, Azpilikueta A, Bolaños E, Anel A, Pardo J, Melero I. J Immunother Cancer. 2013 May 29;1:3.
    ABSTRACT CORTESÍA DE PUBMED 

  • CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy. Hervas-Stubbs S, Mancheño U, Riezu-Boj JI, Larraga A, Ochoa MC, Alignani D, Alfaro C, Morales-Kastresana A, Gonzalez I, Larrea E, Pircher H, Le Bon A, Lopez-Picazo JM, Martín-Algarra S, Prieto J, Melero I. J Immunol. 2012 Oct 1;189(7):3299-310. Epub 2012 Aug 27.
    ABSTRACT CORTESÍA DE PUBMED

  • The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy. Palazón A, Martínez-Forero I, Teijeira A, Morales-Kastresana A, Alfaro C, Sanmamed MF, Perez-Gracia JL, Peñuelas I, Hervás-Stubbs S, Rouzaut A, de Landázuri MO, Jure-Kunkel M, Aragonés J, Melero I. Cancer Discov. 2012 Jul;2(7):608-23. 
    ABSTRACT CORTESÍA DE PUBMED

  • Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates. Unzu C, Hervás-Stubbs S, Sampedro A, Mauleón I, Mancheño U, Alfaro C, de Salamanca RE, Benito A, Beattie SG, Petry H, Prieto J, Melero I, Fontanellas A. J Transl Med. 2012 Jun 15;10:122. 
    ABSTRACT CORTESÍA DE PUBMED

  • Direct effects of type I interferons on cells of the immune system. Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I. Clin Cancer Res. 2011 May 1;17(9):2619-27
    ABSTRACT CORTESÍA DE PUBMED

  • Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice. Gonzalez-Aparicio M, Alzuguren P, Mauleon I, Medina-Echeverz J, Hervas-Stubbs S, Mancheno U, Berraondo P, Crettaz J, Gonzalez-Aseguinolaza G, Prieto J, Hernandez-Alcoceba R. Gut. 2011 Mar;60(3):341-9
    ABSTRACT CORTESÍA DE PUBMED

  • Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells. Hervas-Stubbs S, Riezu-Boj JI, Gonzalez I, Mancheño U, Dubrot J, Azpilicueta A, Gabari I, Palazon A, Aranguren A, Ruiz J, Prieto J, Larrea E, Melero I. Eur J Immunol. 2010 Dec;40(12):3389-402. 
    ABSTRACT CORTESÍA DE PUBMED

  • Proliferating NK cells in response to IL-15 do not upregulate surface B220 in vivo. Murillo O, Ochoa MC, Arina A, Gabari I, Dubrot J, Hervas-Stubbs S, Melero I. Gene Ther. 2010 May;17(5):687-9. 
    ABSTRACT CORTESÍA DE PUBMED

  • Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates. Fontanellas A, Hervás-Stubbs S, Mauleón I, Dubrot J, Mancheño U, Collantes M, Sampedro A, Unzu C, Alfaro C, Palazón A, Smerdou C, Benito A, Prieto J, Peñuelas I, Melero I. Mol Ther. 2010 Apr;18(4):754-65.
    ABSTRACT CORTESÍA DE PUBMED

  • PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector. Fontanellas A, Hervas-Stubbs S, Sampedro A, Collantes M, Azpilicueta A, Mauleón I, Pañeda A, Quincoces G, Prieto J, Melero I, Peñuelas I. Gene Ther. 2009 Jan;16(1):136-41.
    ABSTRACT CORTESÍA DE PUBMED

  • Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells. Arina A, Murillo O, Dubrot J, Azpilikueta A, Gabari I, Perez-Gracia JL, Alfaro C, Berasain C, Prieto J, Ferrini S, Hervas-Stubbs S, Melero I. Gene Ther. 2008 Apr;15(7):473-83. 
    ABSTRACT CORTESÍA DE PUBMED

  • TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Hervas-Stubbs S, Olivier A, Boisgerault F, Thieblemont N, Leclerc C. Blood. 2007 Jun 15;109(12):5318-26. Epub 2007 Mar 5.
    ABSTRACT CORTESÍA DE PUBMED

  • Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. Hervas-Stubbs S, Rueda P, Lopez L, Leclerc C. J Immunol. 2007 Feb 15;178(4):2361-9. Erratum in: J Immunol. 2007 May 15;178(10):6653. 
    ABSTRACT CORTESÍA DE PUBMED

  • High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. Hervas-Stubbs S, Majlessi L, Simsova M, Morova J, Rojas MJ, Nouzé C, Brodin P, Sebo P, Leclerc C. Infect Immun. 2006 Jun;74(6):3396-407.
    ABSTRACT CORTESÍA DE PUBMED



"Mediante técnicas de modificacion génica estamos regulando "immune checkpoints" intracelulares que son claves para la función y diferenciación de los linfocitos T con el objetivo de mejorar la eficacia terapéutica de la transferencia celular adoptiva", Dra. Sandra Hervás-Stubbs.

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Contacto

Contacto:
Cristina López
Avda. Pío XII, 53
31008 Pamplona
España

(+34) 948 194 700 Ext. 6021
clopezg@unav.es