Publicaciones

  • Arribillaga, L., M. Durantez, T. Lozano, F. Rudilla, F. Rehberger, N. Casares, L. Villanueva, M. Martinez, M. Gorraiz, F. Borras-Cuesta, P. Sarobe, J. Prieto, and J. J. Lasarte. 2013. A fusion protein between streptavidin and the endogenous TLR4 ligand EDA targets biotinylated antigens to dendritic cells and induces T cell responses in vivo. Biomed Res Int 2013:864720.

  • San Roman, B., X. De Andres, P. M. Munoz, P. Obregon, A. C. Asensio, V. Garrido, C. Mansilla, L. Arribillaga, J. J. Lasarte, D. De Andres, B. Amorena, and M. J. Grillo. 2012. The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model. Vaccine 30:2564-2569.

  • Rudilla, F., C. Fayolle, N. Casares, M. Durantez, L. Arribillaga, T. Lozano, L. Villanueva, R. Pio, P. Sarobe, C. Leclerc, J. Prieto, and J. J. Lasarte. 2012. Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses. Vaccine 30:2848-2858.

  • Roman, B. S., V. Garrido, P. M. Munoz, L. Arribillaga, B. Garcia, X. De Andres, V. Zabaleta, C. Mansilla, I. Farran, I. Lasa, D. De Andres, B. Amorena, J. J. Lasarte, and M. J. Grillo. 2012. The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice. Vet Res 43:31.

  • Mansilla, C., P. Berraondo, M. Durantez, M. Martinez, N. Casares, L. Arribillaga, F. Rudilla, J. Fioravanti, T. Lozano, L. Villanueva, P. Sarobe, F. Borras, C. Leclerc, J. Prieto, and J. J. Lasarte. 2012. Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin. Int J Cancer 131:641-651.

  • Camacho, A. I., R. Da Costa Martins, I. Tamayo, J. de Souza, J. J. Lasarte, C. Mansilla, I. Esparza, J. M. Irache, and C. Gamazo. 2011. Poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as innate immune system activators. Vaccine 29:7130-7135.

  • Aranda, F., D. Llopiz, N. Diaz-Valdes, J. I. Riezu-Boj, J. Bezunartea, M. Ruiz, M. Martinez, M. Durantez, C. Mansilla, J. Prieto, J. J. Lasarte, F. Borras-Cuesta, and P. Sarobe. 2011. Adjuvant combination and antigen targeting as a strategy to induce polyfunctional and high-avidity T-cell responses against poorly immunogenic tumors. Cancer Res 71:3214-3224.

  • Tamayo, I., J. M. Irache, C. Mansilla, J. Ochoa-Reparaz, J. J. Lasarte, and C. Gamazo. 2010. Poly(anhydride) nanoparticles act as active Th1 adjuvants through Toll-like receptor exploitation. Clin Vaccine Immunol 17:1356-1362.

  • Farran, I., I. McCarthy-Suarez, F. Rio-Manterola, C. Mansilla, J. J. Lasarte, and A. M. Mingo-Castel. 2010. The vaccine adjuvant extra domain A from fibronectin retains its proinflammatory properties when expressed in tobacco chloroplasts. Planta 231:977-990.

  • Durantez, M., C. Fayolle, N. Casares, V. Belsue, J. I. Riezu-Boj, P. Sarobe, J. Prieto, F. Borras-Cuesta, C. Leclerc, and J. J. Lasarte. 2010. Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis. Vaccine 28:7146-7154.

  • Mansilla, C., M. Gorraiz, M. Martinez, N. Casares, L. Arribillaga, F. Rudilla, I. Echeverria, J. I. Riezu-Boj, P. Sarobe, F. Borras-Cuesta, J. Prieto, and J. J. Lasarte. 2009. Immunization against hepatitis C virus with a fusion protein containing the extra domain A from fibronectin and the hepatitis C virus NS3 protein. J Hepatol 51:520-527.

  • Lasarte, J. J., N. Casares, M. Gorraiz, S. Hervas-Stubbs, L. Arribillaga, C. Mansilla, M. Durantez, D. Llopiz, P. Sarobe, F. Borras-Cuesta, J. Prieto, and C. Leclerc. 2007. The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo. J Immunol 178:748-756.



"Hemos desarrollado estrategias de vacunación que se están evaluando en ensayos clínicos y han dado logar a la generación de compañías spin-off", Dr. Juan José Lasarte.

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Contacto

Contacto:
Cristina López
Avda. Pío XII, 53
31008 Pamplona
España

(+34) 948 194 700 Ext. 6021
clopezg@unav.es