HC-Ad vectors: High-capacity adenoviral vectors

  • High‐Capacity adenoviral vectors (HC‐Ad), also called helper‐dependent or ‘gutless' are a new class of gene therapy vectors that allow stable transfer of large DNA fragments in vivo.

  • A new method for production of high‐quality HC‐Ad with potential applications in humans has been developed, based on a self‐inactivating adenovirus acting as a helper virus (HV).

  • Indications: monogenic diseases, cancer, liver cirrhosis and metabolic diseases.

>> Download information

Gene therapy product for Acute Intermittent Porphyria: Phase I Clinical trial

  • Adenoassociated viral (AAV) vectors are very promising tools for therapeutic gene delivery, since they are safe and they induce an efficient and long‐term transduction.

  • In collaboration with uniQure a gene therapy product for the treatment of Acute Intermittent Porphyria has been developed and is currently being evaluated in phase I clinical trial.

  • A new AAV expression system has been developed and an AAV production system has been  optimized.

    • AAV tetracycline‐inducible system  

    • liver and brain specific expression.

>> Download information


Programas de investigación

Programas de investigación en los que puede participar con el CIMA

Acuerdos y programas de investigación del CIMA [PDF]

"CIMA Lab Diagnostics"


Su objetivo es optimizar con el máximo nivel de calidad e innovación el abanico de diagnósticos genéticos e inmunofenotípicos que se desarrollan en diferentes laboratorios de la Universidad de Navarra.

Ir a empresas

Contacta con nosotros

Contacto:
Centro de Investigación Médica Aplicada (CIMA)
Avenida Pío XII, 55
31008 Pamplona
España

+34 948 194 700
cima@unav.es