Parkinson's disease is a neurodegenerative disease whose clinical symptoms are mainly caused by the loss of substantia nigra dopaminergic neurons. The main problem, for both researchers and clinical practitioners, is that when patients present the first symptoms, somewhere between 70% and 80% of their dopaminergic neurons have disappeared.
Our group focuses on the study of the functional anatomy of the basal ganglia, regenerative therapy, and the search for neuroprotective strategies.
The Regenerative Therapy Laboratory is made up of scientists and doctors from Clínica Universidad de Navarra and works in the following areas:
- The study of the molecular mechanisms involved in the death of dopaminergic neurons of the substantia nigra, with particular interest in determining the role played by ɑ-synuclein and LRRK2.
- The study of the mechanisms that regulate neurogenesis in the adult brain and how it is modified in animal models of Parkinson's disease.
- The study of the potential of gene therapy is a tool for the intracerebral administration of trophic factors.