Publications

  • Alzuguren P, Hervas-Stubbs S, Gonzalez-Aseguinolaza G, Poutou J, Fortes P,Mancheno U, Bunuales M, Olagüe C, Razquin N, Van Rooijen N, Enguita M,Hernandez-Alcoceba R. Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver. Liver Int. 2014 Apr 22. 

  • Hernandez-Alcoceba R, Sangro B, Berraondo P, Gonzalez-Aseguinolaza G, Prieto J. Cytokines for the treatment of gastrointestinal cancers: clinical experience and new perspectives. Expert Opin Investig Drugs. 2013 Jul;22(7):827-41. 

  • Parra-Guillen ZP, Janda A, Alzuguren P, Berraondo P, Hernandez-Alcoceba R, Troconiz IF. Target-mediated disposition model describing the dynamics of IL12 and IFNγ after administration of a mifepristone-inducible adenoviral vector for IL-12 expression in mice. AAPS J. 2013 Jan;15(1):183-94. 

  • Bunuales M, Garcia-Aragoncillo E, Casado R, Quetglas JI, Hervas-Stubbs S, Bortolanza S, Benavides-Vallve C, Ortiz-de-Solorzano C, Prieto J, Hernandez-Alcoceba R. Evaluation of monocytes as carriers for armed oncolytic adenoviruses in murine and Syrian hamster models of cancer. Hum Gene Ther. 2012 Dec;23(12):1258-68. 

  • Hernandez-Alcoceba R, Berraondo P. Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin. Oncoimmunology. 2012 Jan 1;1(1):97-99. 

  • Gonzalez-Aparicio M, Mauleon I, Alzuguren P, Bunuales M, Gonzalez-Aseguinolaza G, San Martín C, Prieto J, Hernandez-Alcoceba R. Self-inactivating helper virus for the production of high-capacity adenoviral vectors. Gene Ther. 2011. Nov;18(11):1025-33. 

  • Smerdou C, Menne S, Hernandez-Alcoceba R, Gonzalez-Aseguinolaza G. Gene therapy for HCV/HBV-induced hepatocellular carcinoma. Curr Opin Investig Drugs.2010 Dec;11(12):1368-77. 

  • Gonzalez-Aparicio M, Alzuguren P, Mauleon I, Medina-Echeverz J, Hervas-Stubbs S, Mancheno U, Berraondo P, Crettaz J, Gonzalez-Aseguinolaza G, Prieto J, Hernandez-Alcoceba R. Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice. Gut. 2011 Mar;60(3):341-9. 



"Adaptation of adenovirus as vehicles for the transfer of therapeutic genes in cancer and congenital diseases", Rubén Hernández, PhD and Principal Investigator of adenovirus vectors

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Contact

Contact:
Cristina López
Avda. Pío XII, 53
31008 Pamplona
Spain

(+34) 948 194 700 Ext. 6021
clopezg@unav.es