Publications

  • Kambara H, Niazi F, Kostadinova L, Moonka DK, Siegel CT, Post AB, Carnero E, Barriocanal M, Fortes P, Anthony DD, Valadkhan S. Negative regulation of the interferon response by an interferon-induced long non-coding RNA. Nucleic Acids Res. In press
    ABSTRACT CORTESÍA DE PUBMED

  • M Enguita, P Fortes. Targeting IGF pathway in hepatocellular carcinoma. In press.

  • L Blazquez, P Fortes. U1 interference (U1i) for antiviral approaches. In press.

  • P Alzuguren, S Hervas-Stubbs, G Gonzalez-Aseguinolaza, P Fortes, U Mancheno, C Olagüe, N Razquin, N Van Rooijen, M Enguita, R Hernandez-Alcoceba. Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver. Liver International. In press. 

  • S Colnot, P Fortes. Editing liver tumours. Gut 63: 709-710. 2014
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  • L Blazquez, P Fortes. Harnessing RNAi for the treatment of viral infections. Chapter 9. Applied RNAi. Caister Academic Press. 2014.

  • Llorens F, Carulla P, Villa A, Torres JM, Fortes P, Ferrer I, Del Río JA. PrPC regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells. J Neurochem 127: 124-138. 2013
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  • A Garitano-Trojaola, X Agirre, F Prósper, P Fortes. Long non-coding RNAs in haematological malignancies. International Journal of Molecular Sciences 14: 15386-15442. 2013.
    ABSTRACT CORTESÍA DE PUBMED

  • L Blázquez, A Aiastui, M Goicoechea, M Martins de Araujo, A Avril, C Beley, L García, J Valcárcel, P Fortes*, A. López de Munain*. In vitro correction of a pseudoexon-generating deep intronic mutation in LGMD2A by antisense oligonucleotides and modified small nuclear RNAs. Human mutation 34: 1387-1395. 2013
    ABSTRACT CORTESÍA DE PUBMED

  • L Blazquez, P Fortes. U1 snRNP control of 3´-end processing and the therapeutic application of U1 inhibition combined with RNA interference. Current Mol Med 13: 1203-1216. 2013
    ABSTRACT CORTESÍA DE PUBMED

  • SA Knoepfel, A Abad, X Abad, P Fortes, and B Berkhout. Design of modified U1i molecules against HIV-1 RNA. Antiviral research 94: 208-216. 2012
    ABSTRACT CORTESÍA DE PUBMED

  • L Blazquez, S J Gonzalez-Rojas, A Abad, N Razquin1, X Abad, P Fortes. Increased in vivo inhibition of expression by combining RNA interference and U1 inhibition. Nucl Acids Res 40: e8. 2012
    ABSTRACT CORTESÍA DE PUBMED

  • L. Sobrevals, M. Enguita, C. Rodriguez, J. Gonzalez-Rojas, P. Alzaguren, N. Razquin, J. Prieto y P. Fortes. AAV vectors transduce hepatocytes in vivo as efficiently in cirrhotic as in healthy rat livers. Gene Therapy 19: 411-417. 2012
    ABSTRACT CORTESÍA DE PUBMED

  • N Bitarte, E Bandres, V Boni, R Zarate, J Rodriguez, M Gonzalez-Huarriz, I Lopez, J J Sola, M M Alonso, P Fortes* J Garcia-Foncillas*. MicroRNA-451 is involved in the self-renewal, tumorigenicity and chemoresistance of colorectal cancer stem cells. Stem Cells 29: 1661-1671. 2011.
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  • E. Carnero, J. Sutherland, P. Fortes. Adenovirus and microRNAs. : BBA Gene Regulatory mechanisms 1809: 660-667. 2011
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  • Koornneef A, van Logtenstein R, Timmermans E, Pisas L, Blits B, Abad X, Fortes P, Petry H, Konstantinova P, Ritsema T. AAV-mediated in vivo knockdown of luciferase using combinatorial RNAi and U1i. Gene Therapy 18: 929-935. 2011.
    ABSTRACT CORTESÍA DE PUBMED

  • X. Abad, N. Razquin, A. Abad y P. Fortes. Combination of RNA interference and U1 inhibition leads to increased inhibition of gene expression. Nucleic Acids Res 38: e136. 2010.
    ABSTRACT CORTESÍA DE PUBMED

  • O. Aparicio, E. Carnero, X. Abad, N. Razquin, E. Guruceaga, V. Segura y P Fortes. Adenovirus VA RNA-derived miRNAs target cellular genes involved in cell growth, gene expression and DNA repair. Nucleic Acids Res 38: 750-763. 2010
    ABSTRACT CORTESÍA DE PUBMED

  • L. Sobrevals, C. Rodriguez, JL Romero-Trevejo, G. Gondi, I. Monreal, A. Pañeda, N. Juanarena, S. Arcelus, N. Razquin, L. Guembe, G. González-Aseguinolaza, J. Prieto y P. Fortes. IGF-I gene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats. Hepatology 51: 912-921. 2010.
    ABSTRACT CORTESÍA DE PUBMED

  • J. González-Rojas, X. Abad y P. Fortes. RNAi with viral vectors that deliver small interference RNAs (siRNAs). Horizon Scientific Press 11: 197-251. 2010

  • Agirre X, Vilas-Zornoza A, Jiménez-Velasco A, Martin-Subero JI, Cordeu L, Gárate L, San José-Eneriz E, Abizanda G, Rodríguez-Otero P, Fortes P, Rifón J, Bandrés E, Calasanz MJ, Martín V, Heiniger A, Torres A, Siebert R, Román-Gomez J, Prósper F. Epigenetic silencing of the tumor suppressor microRNA hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in Acute Lymphoblastic Leukemia. Cancer Res 69: 4443-4453. 2009.
    ABSTRACT CORTESÍA DE PUBMED

  • E. Bandres, N. Bitarte, F. Arias, J. Agorreta, P. Fortes, X. Agirre, R. Zarate, J.A. Diaz-Gonzalez, N. Ramirez, J.J. Sola, P. Jimenez, J. Rodriguez, J. Garcia-Foncillas. microRNA-451 regulates Macrophage Migration Inhibitory Factor Production and Proliferation of Gastrointestinal Cancer Cells. Clinical Cancer Research 15: 2281-2290. 2009.
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  • X. Agirre, A. Jiménez-Velasco, E. San José-Enériz, L. Garate, E. Bandrés, L. Cordeu, O. Aparicio, B. Saez, G. Navarro, A. Vilas-Zornoza, I. Pérez-Roger, J. García-Foncillas, A. Torres, A. Heiniger, M. J. Calasanz, P. Fortes, J. Román-Gómez, F. Prósper. Down-regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ cells increases (USF2 mediated) cell growth. Molecular Cancer Research 6: 1830-1840. 2008.
    ABSTRACT CORTESÍA DE PUBMED

  • X. Abad, M. Vera, S. P. Jung, E. Oswald, I. Romero, V. Amin, P. Fortes*, S. I. Gunderson*. Requirements for gene silencing mediated by U1 snRNA binding to a target sequence. Nucleic Acids Res 36: 2338-2352. 2008.
    ABSTRACT CORTESÍA DE PUBMED

  • P. Fortes, D. Longman, S. McCracken, R. Poot, I. W. Mattaj, J. F. Cáceres y B. J. Blencowe. Identification and characterization of RED120: a new exon junction complex protein. FEBS Letters 581. 3087-3097. 2007
    ABSTRACT CORTESÍA DE PUBMED

  • M. Vera, L. Sobrevals, M. Zaratiegui, L. Martinez, B. Palencia, C. M. Rodríguez, J. Prieto, y P. Fortes. Liver transduction with a SV40 vector encoding insulin-like growth factor I reduces hepatic damage and the development of liver cirrhosis. Gene Therapy 14: 203-210. 2007.
    ABSTRACT CORTESÍA DE PUBMED

  • M. Iñiguez, C. Berasain, E. Martinez-Ansó, M. Bustos, P. Fortes, D. Pennica, M. A. Avila, and J. Prieto. Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning. J. Exp Med 203: 2809-2815. 2006.
    ABSTRACT CORTESÍA DE PUBMED

  • I. Narvaiza, O. Aparicio, M. Vera, N. Razquin, S. Bortolanza, J. Prieto y P. Fortes. Effect of adenovirus-mediated RNA interference on endogenous micro-RNA functionality in a mouse model of Multidrug Resistance Protein-2 gene silencing. J. Virology 80: 12236-12247. 2006.
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  • I. Tirapu, E. Huarte, C. Guiducci, A. Arina, M. Zaratiegui, O. Murillo, A. Gonzalez, C. Berasain, P. Berraondo, P. Fortes, J. Prieto, M. P. Colombo, L. Chen y I. Melero. Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma. Cancer Res 66: 2442-2450. 2006.
    ABSTRACT CORTESÍA DE PUBMED

  • O. Aparicio, N. Razquin, M. Zaratiegui, I. Naravaiza y P. Fortes. Adenovirus VA RNA is processed to functional interfering RNAs involved in virus production. J. Virology 80: 1376-1384. 2006.
    ABSTRACT CORTESÍA DE PUBMED

  • M. Vera, N. Razquin, J. Prieto, I. Melero, P. Fortes* y G. González-Aseguinolaza* Intratumor injection of dendritic cells transduced by a SV40-based vector expressing interleukin-15 induces curative immunity mediated by CD8+ T lymphocytes and NK cells. Mol Therapy 12: 950-959. 2005.
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  • H. J. McKee, P. Y. T'sao, M. Vera, P. Fortes y D. S. Strayer. Durable Cytotoxic Immune Responses Against gp120 Elicited by Recombinant SV40 Vectors Encoding HIV-1 gp120 ± IL-15. Genetic Vaccines and Therapy 2: 10-21. 2004.
    ABSTRACT CORTESÍA DE PUBMED

  • M. Vera, D. Strayer, J. Prieto y P. Fortes. Factors influencing the production of recombinant SV40 vectors. Mol. Therapy 10: 780-791. 2004.
    ABSTRACT CORTESÍA DE PUBMED

  • M. Vera y P. Fortes. Simian virus 40 as a gene therapy vector. DNA and Cell Biology 23: 271-282. 2004

  • P. Fortes, Y. Cuevas, F. Guan, P. Liu, S. Pentlicky, S. Jung, M. L. Martínez-Chantar, J. Prieto, D. Rowe y S. I. Gunderson. : Inhibiting expression of specific genes in mammalian cells with 5´end-mutated U1 snRNAs targeted to terminal exons of pre-mRNA. PNAS 100: 8264-8269. 2003.
    ABSTRACT CORTESÍA DE PUBMED

  • J. Baron-Benhamou, P. Fortes T. Inada, T. Preiss y M. W. Hentze. The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast. RNA 9: 654-662. 2003.
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  • M. L. Martínez–Chantar, E. R. García–Trevijano, M. U. Latasa, A. Martín–Duce, P. Fortes, J. Caballería, M. A. Avila y J. M. Mato. Methionine Adenosyltransferase II b Subunit Gene Expression Provides a Proliferative Advantage in Human Hepatoma. Gastroenterology 124: 940-948. 2003
    ABSTRACT CORTESÍA DE PUBMED

  • M. G. Kramer, M. A. Barajas, N. Razquin, P. Berraondo, M. Rodrigo, C. Wu, C. Qian, P. Fortes* y J. Prieto*.  In vitro and in vivo comparative study of chimeric liver specific promoters. Molecular Therapy 7: 375-385. 2003.
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  • P. Fortes, T. Inada, T. Preiss, M. Hentze, , I. W. Mattaj y A. Sachs. The nuclear cap binding complex interacts with the translation initiation machinery and promotes translation in the absence of eIF4E. Molecular Cell 6: 191-196. 2000.
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"We have developed viral vectors that inhibit the expression of target genes by expressing short RNA molecules, and which are very effective in cells in cultures and animal models", Dra. Puri Fortes, Principal Investigator.

More information:

Contacto

Contact:
Cibeles Pinto
Avda. Pío XII, 53
31008 Pamplona
España

+34 948 194 700 Ext. 4012
mcpinto@unav.es