Publicaciones

  • Villanueva L, Silva L, Llopiz D, Ruiz M, Iglesias T, Lozano T, Casares N, Hervas-Stubbs S, Rodríguez MJ, Carrascosa JL, Lasarte JJ, Sarobe P. "The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer" Oncoimmunology. 2017 Dec 21;7(4):e1409321. doi: 10.1080/2162402X.2017.1409321. eCollection 2018.

  • Lasarte-Cia A, Lozano T, Pérez-González M, Gorraiz M, Iribarren K, Hervás-Stubbs S, Sarobe P, Rabal O, Cuadrado-Tejedor M, García-Osta A, Casares N, Lasarte JJ. “Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice” Front Immunol. 2018 Jan 25;9:68. doi: 10.3389/fimmu.2018.00068. eCollection 2018.

  • Gato-Cañas M, Zuazo M, Arasanz H, Ibañez-Vea M, Lorenzo L, Fernandez-Hinojal G, Vera R, Smerdou C, Martisova E, Arozarena I, Wellbrock C, Llopiz D, Ruiz M, Sarobe P, Breckpot K, Kochan G, Escors D. “PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity” Cell Rep. 2017 Aug 22;20(8):1818-1829. doi: 10.1016/j.celrep.2017.07.075.

  • Llopiz D, Ruiz M, Infante S, Villanueva L, Silva L, Hervas-Stubbs S, Alignani D, Guruceaga E, Lasarte JJ, Sarobe P. “IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination” Oncotarget. 2017 Jan 10;8(2):2659-2671. doi: 10.18632/oncotarget.13736.

  • Llopiz D, Aranda F, Díaz-Valdés N, Ruiz M, Infante S, Belsúe V, Lasarte JJ, Sarobe P. “Vaccine-induced but not tumor-derived Interleukin-10 dictates the efficacy of Interleukin-10 blockade in therapeutic vaccination” Oncoimmunology. 2015 Aug 12;5(2):e1075113. eCollection 2016 Feb.

  • Zabaleta A, Riezu-Boj JI, Larrea E, Villanueva L, Lasarte JJ, Guruceaga E, Fisicaro P, Ezzikouri S, Missale G, Ferrari C, Benjelloun S, Prieto J, Sarobe P. “Gene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance” J Med Virol. 2016 May;88(5):843-51. doi: 10.1002/jmv.24399.

  • Zabaleta A, D'Avola D, Echeverria I, Llopiz D, Silva L, Villanueva L, Riezu-Boj JI, Larrea E, Pereboev A, Lasarte JJ, Rodriguez-Lago I, Iñarrairaegui M, Sangro B, Prieto J, Sarobe P. “Clinical testing of a dendritic cell targeted therapeutic vaccine in patients with chronic hepatitis C virus infection” Mol Ther Methods Clin Dev. 2015 Mar 11;2:15006. doi: 10.1038/mtm.2015.6. eCollection 2015.

  • Flecken T, Sarobe P. “Tim-3 expression in tumour-associated macrophages: a new player in HCC progression” Gut. 2015 Oct;64(10):1502-3. doi: 10.1136/gutjnl-2014-309094.

  • Larrea E, Echeverria I, Riezu-Boj JI, Aldabe R, Guembe L, Sola I, Civeira MP, Sarobe P, Prieto J. “Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection” J Hepatol. 2014 Mar;60(3):482-9. doi: 10.1016/j.jhep.2013.10.016.

  • Larrea E, Riezu-Boj JI, Aldabe R, Guembe L, Echeverria I, Balasiddaiah A, Gastaminza P, Civeira MP, Sarobe P, Prieto J. “Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes” Gut. 2014 Apr;63(4):665-73. doi: 10.1136/gutjnl-2012-304377.

  • Llopiz D, Huarte E, Ruiz M, Bezunartea J, Belsúe V, Zabaleta A, Lasarte JJ, Prieto J, Borrás-Cuesta F, Sarobe P. “Helper cell-independent antitumor activity of potent CD8+ T cell epitope peptide vaccines is dependent upon CD40L” Oncoimmunology. 2013 Dec 1;2(12):e27009.

  • Arribillaga L, Durantez M, Lozano T, Rudilla F, Rehberger F, Casares N, Villanueva L, Martinez M, Gorraiz M, Borrás-Cuesta F, Sarobe P, Prieto J, Lasarte JJ. “A fusion protein between streptavidin and the endogenous TLR4 ligand EDA targets biotinylated antigens to dendritic cells and induces T cell responses in vivo” Biomed Res Int. 2013;2013:864720. doi: 10.1155/2013/864720. 



""We have shown the different strategies that potentiate the activation the dendritic cells increase the effect of the vaccines. This has given rise to different vaccination protocols, which have been trialed in patients", Dr. Pablo Sarobe, Principal Investigator.

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Contact

Contact:
Cristina López
Avda. Pío XII, 55
31008 Pamplona
Spain

(+34) 948 194 700 Ext. 6021
clopezg@unav.es